Description

MOTS-C Research Topics:

1. Metabolic Health:

   MOTS-C enhances glucose uptake and utilization by skeletal muscle, improving insulin sensitivity and aiding in glucose homeostasis. This is particularly beneficial for managing conditions like obesity and type 2 diabetes. (PMID: 33554779, PMID: 33473109)

2. Anti-Inflammatory Effects:

   MOTS-C reduces levels of pro-inflammatory factors and increases anti-inflammatory factors, which can help mitigate metabolic and inflammatory diseases. (PMID: 31926126)

3. Exercise Mimetic:

   MOTS-C mimics the effects of exercise by increasing mitochondrial function and enhancing physical endurance. This can be particularly beneficial for individuals who are unable to engage in regular physical activity. (PMID: 33473109)

4. Longevity and Anti-Aging:

   The peptide has been associated with improved longevity and anti-aging effects by promoting cellular homeostasis and stress resistance. (PMID: 36670507)

Peer-Reviewed Studies

• The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance Lee, C., Zeng, J., Drew, B. G., Sallam, T., Martin-Montalvo, A., Wan, J., … & Cohen, P. (2015). Cell metabolism, 21(3), 443-454.

• MOTS-c: a mitochondrial‐encoded regulator of the nucleus Benayoun, B. A., & Lee, C. (2019). BioEssays, 41(9), 1900046.

Structure

Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg

Molecular Formula: C H N O S Molecular Weight: 2174.64 g/mol

PubChem SID: 255386757

CAS Number: 1627580-64-6

Synonyms: Mitochondrial open reading frame of the 12S rRNA-c, MT-RNR1