Description

BPC-157 promotes gastrointestinal healing, enhances muscle and tendon repair, and has neuroprotective effects, making it beneficial for recovery from injuries and neurological conditions. (PMID: 15840402, 36551977, 37242459)

BPC-157 Research Topics:

1. Gastrointestinal Healing:

   BPC-157 has been shown to significantly aid in healing inflammatory bowel disease and other gastrointestinal conditions by promoting tissue repair and reducing inflammation. (PMID: 15840402)

2. Muscle and Tendon Healing:

   This peptide enhances the healing of muscles, tendons, and ligaments, making it beneficial for recovery from injuries. (PMID: 36551977)

3. Neuroprotective Effects:

   BPC-157 supports brain-gut axis functions and has potential neuroprotective effects, aiding in the recovery of neurological functions. (PMID: 37242459)

Peer-Reviewed Studies 

• BPC 157’s effect on healing

Seiwerth, S., Sikiric, P., Grabarevic, Z., Zoricic, I., Hanzevacki, M., Ljubanovic, D., … & Kolega, Z. (1997)

Journal of Physiology-Paris, 91(3-5), 173-178.

• Effective therapy of transected quadriceps muscle in rat: Gastric pentadecapeptide BPC 157

Staresinic, M., Petrovic, I., Novinscak, T., Jukic, I., Pevec, D., Suknaic, S., … & Sikiric, P. (2006)

Journal of orthopaedic research, 24(5), 1109-1117.

 Structure

Source: PubChem

Sequence: Gly- Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala­Asp-Asp-Ala-Gly-Leu-Val
Molecular Formula: Cs2HgaN1s022
Molecular Weight: 1419.556 g/mol
PubChem CID: 108101

Referenced Citations

1. T. Huang et al., “Body protective compound-157 enhances alkali-burn wound healing and Promotes Proliferation, migration, and angiogenesis in vitro,” Drug Des. Devel. Ther., vol. 9, RR- 2485-2499, 2015.
2. D. Drmic et al., “Counteraction of perforated cecum lesions in rats: Effects of pentadecapeptide BPC 157, L-NAME and L­-arginine,” World J. Gastroenterol.1 vol. 24, no. 48, pp. 5462-5476, Dec. 2018.
3. F. Amie et al., “By Passing major venous occlusion and duodenal lesions in rats, and therapy with the stable gastric pentadecapeptide BPC 157, L-NAME and L­arginine,” World J. Gastroenterol.1 vol. 24, no. 47, QQ. 5366-5378, Dec. 2018.
4. A. Duzel et al., “Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and ischemia and reperfusion in rats: New insights,” World J. Gastroenterol., vol. 23, no. 48, QQ. 8465-8488, Dec. 2017.
5. J. Vukojevic et al., “Rat inferior caval vein_{ICV) ligature and particular new insights with the stable gastric pentadecapeptide BPC 157,” Vascul. Pharmacol., vol. 106, QQ. 54- 66, 2018.
6. D. Drmic et al., “Celecoxib-induced gastrointestinal, liver and brain lesions in rats, counteraction by BPC 157 or L-arginine, aggravation by L-NAME,” World J. Gastroenterol., vol. 23, no. 29, QQ. 5304- 5312, Aug. 2017.
7. M.-J. Hsieh et al., “Therapeutic Potential of Pro-angiogenic BPC157 is associated with VEGFR2 activation and LIQ-regulation,” J. Mol. Med. Berl. Ger., vol. 95, no. 3, QQ. 323- 333, 2017.
8. Z. Grabarevic et al., “The influence of BPC 157 on nitric oxide agonist and antagonist induced lesions in broiler chicks,” J. Physiol. Paris, vol. 91, no. 3-51 P- 139-149, Oct. 1997.
9. P. Sikiric et al., “Novel Cytoprotective Mediator, Stable Gastric Pentadecapeptide BPC 157. Vascular Recruitment and Gastrointestinal Tract Healing,” Curr. Pharm. Des., vol. 24, no. 18, pp. 1990-2001, 2018.
10. S. Seiwerth et al., “BPC 157 and Standard Angiogenic Growth Factors. Gastrointestinal Tract Healing, Lessons from Tendon, Ligament, Muscle and Bone Healing,” Curr. Pharm. Des., vol. 24, no. 18, pp. 1972-1989, 2018.
11. C.-H. Chang, W.-C. Tsai, M.-S. Lin, Y.-H. Hsu, and J.-H. S. Pang, “The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration,” J. Appl. Physiol., vol. 110, no. 3, pp. 774-780, Oct. 2010.
12. Y.-L. Hu et al., “FAK and paxillin dynamics at focal adhesions in the protrusions of migrating cells,” Sci. Rep., vol. 41 p. 6024, Aug. 2014.
13. K. Skrlec et al., “Engineering recombinant Lactococcus lactis as a delivery vehicle for BPC-157 peptide with antioxidant activities,” ppl. Microbial. Biotechnol., vol. 102, no. 23, pp. 10103-10117, Dec. 2018.
14. D. Strinic et al., “BPC 157 counteracts QTc prolongation induced by haloperidol, flurhenazine, clozapine, olanzapine, quetiapine. sulpiride, and metoclopramide in rats,” Life Sci., vol. 186, RR- 66-79, Oct. 2017.
15. N. Jelovac et al. 1 “Pentadecapeptide BPC 157 attenuates disturbances induced by neuroleptics: the effect on catalepsy. and gastric ulcers in mice and rats,” Eur. J. Pharmacol., vol. 379, no. 1, PR· 19-31, Aug.:. 1999.
16. I. Tlak Gajger, J. Ribaric, M. Smodis Skerl, J. Vlainic, and P. Sikiric, “Stable gastric pentadecapeptide BPC 157 in honeybee (Apiis mellifera) therapv, to control Nosema ceranae invasions in apiary. conditions,” J. Vet. Pharmacol. Ther., vol. 41, no. 4, pp. 614- 621, Aug. 2018.